The US Open semi-final lineups will be completed when Wednesday’s action on the Arthur Ashe Stadium court wraps.
In the men’s singles, we already know that Casper Ruud will face Karen Kachanov in one semi-final.
The settled women’s singles semi-final is a meeting between 17th seed Caroline Garcia of France and Tunisia’s Ons Jabeur.
Frances Tiafoe and Jessica Pegula are the last two Americans left standing, and their matches will take centre stage on either side of the afternoon break.
Follow the US Open with live men’s singles scores
Before the home hopes defend the star-spangled banner though, Czech star Karolina Pliskova faces a flagless Aryna Sabalenka in the opening match of the day on centre court.
US Open action at the Arthur Ashe Stadium gets underway at 17:00 BST (12:00 local time).
Tiafoe also faces a bannerless player in Andrey Rublev who will be out to keep hopes of an all-Russian US Open final alive.
‘Big Foe’ downing a Russian threat would be a crowd pleaser on centre court in the wake of his incredible upset of Rafael Nadal last time out.
Follow the US Open with live women’s singles scores
Pegula faces the daunting task of carrying American hopes in the women’s singles against World No 1 Iga Swiatek.
Their women’s singles quarter-final kicks off an evening session scheduled to start at midnight BST.
Jannik Sinner and Carlos Alcaraz will settle the men’s semi-final lineup in the final match of the day on Centre Court.
Sinner and Alcaraz have already contested a thrilling Grand Slam battle this season with the Italian coming out on top in the fourth round at Wimbledon.
The stakes are higher for Alcaraz this time, having lost the last two against Sinner, while he harbours hopes of becoming the new World No 1 through his exploits at Flushing Meadows.
All times BST.
17:00 Karolina Pliskova (CZE x22) v Aryna Sabalenka (x6)
Not before 19:00 Jannik Sinner (ITA x11) v Carlos Alcaraz (ESP x3)
00:00 Iga Swiatek (POL x1) v Jessica Pegula (USA x8)
Not before 01:15 Andrey Rublev (x9) v Frances Tiafoe (USA x22)
Tennis fans in the UK will need to be in possession of an Amazon Prime subscription to get their fill of the US Open action.
Amazon Prime holds the exclusive rights to broadcast the US Open in the UK with all matches also available to be rewatched through Prime Video on demand.
In the USA, ESPN is the exclusive broadcast partner for the eighth year in succession.
ESPN coverage will be split between their primary channel, ESPN2 ESPN3, ESPN+ and the ESPN App.
Additional broadcast partners:
SPOTV / Eclat: Mongolia, Brunei, Cambodia, East Timor, Hong Kong, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, South Korea, Thailand, Vietnam and Macau
Spark Sport: New Zealand
Channel 9 / Stan Sport: Australia
Sony Sport Network: Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan and Sri Lanka
Digicel: Cook Islands, Fiji, French Polynesia, Nauru, New Caledonia, Solomon Islands, Tahiti, Tokelau, Tonga, Tuvalu, Vanuatu, Wallis & Futuna, Western Samoa and Papua New Guinea
SuperSport: South Africa, Nigeria and other sub-Saharan African countries.

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